Open AccessPancreatic Cancer Stem-Like Cells With High Calreticulin Expression Associated With Immune Surveillance
Author(s) -
Yasuhiro Fujiwara,
Ryouichi Tsunedomi,
Kiyoshi Yoshimura,
Satoshi Matsukuma,
Norio Fujiwara,
Mitsuo Nishiyama,
Shinsuke Kanekiyo,
Hiroto Matsui,
Yoshitaro Shindo,
Yukio Tokumitsu,
Shigeo Yoshida,
Michihisa Iida,
Nobuaki Suzuki,
Shigeru Takeda,
Tatsuya Ioka,
Shoichi Hazama,
Hiroaki Nagano
Publication year - 2021
Publication title -
pancreas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.061
H-Index - 104
eISSN - 1536-4828
pISSN - 0885-3177
DOI - 10.1097/mpa.0000000000001772
Subject(s) - calreticulin , immune system , biology , cancer stem cell , flow cytometry , cancer research , side population , cell , stem cell , population , cancer cell , pancreatic cancer , cluster of differentiation , cancer , immunology , microbiology and biotechnology , medicine , biochemistry , endoplasmic reticulum , genetics , environmental health
Pancreatic cancer stem-like cells (P-CSLCs) are thought to be associated with poor prognosis. Previously, we used proteomic analysis to identify a chaperone pro-phagocytic protein calreticulin (CALR) as a P-CSLC-specific protein. This study aimed to investigate the association between CALR and P-CSLC.