Open AccessNeutrophil Gelatinase–Associated Lipocalin Protects Acinar Cells From Cerulein-Induced Damage During Acute Pancreatitis
Author(s) -
Rakesh Bhatia,
Sakthivel Muniyan,
Christopher Thompson,
Sukwinder Kaur,
Maneesh Jain,
Rakesh K. Singh,
Amaninder J. Dhaliwal,
Jesse L. Cox,
Shizuo Akira,
Shailender Singh,
Surinder K. Batra,
Sushil Kumar
Publication year - 2020
Publication title -
pancreas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.061
H-Index - 104
eISSN - 1536-4828
pISSN - 0885-3177
DOI - 10.1097/mpa.0000000000001690
Subject(s) - lipocalin , acinar cell , viability assay , reactive oxygen species , propidium iodide , gelatinase , pancreatitis , endothelial stem cell , biology , medicine , apoptosis , endocrinology , chemistry , programmed cell death , matrix metalloproteinase , microbiology and biotechnology , biochemistry , in vitro
Elevated neutrophil gelatinase-associated lipocalin (NGAL) is a promising marker for severe acute pancreatitis (SAP) and multiple organ failure, suggesting systemic and local contributions during pancreatitis. We investigated the role of NGAL locally on acinar cell biology.