Open AccessNuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis
Author(s) -
Yuyang Chen,
Wanling Li,
Rui Xie,
Bo Tang,
Yufeng Xiao,
Feng Yang,
Siyuan Chen,
Senyuan Yu,
Shiming Yang,
Hui Dong,
Hong Guo,
Jingjing Liu
Publication year - 2020
Publication title -
pancreas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.061
H-Index - 104
eISSN - 1536-4828
pISSN - 0885-3177
DOI - 10.1097/mpa.0000000000001465
Subject(s) - microbiology and biotechnology , transcription factor , pathogenesis , downregulation and upregulation , chemistry , acinar cell , pancreatitis , biology , medicine , immunology , gene , biochemistry
The mechanisms underlying pathogenesis of acute pancreatitis (AP) are still not completely understood. An early, critical feature of AP is aberrant calcium (Ca) signaling, termed Ca overload, within pancreatic acinar cells. This study aimed to develop a model system in rats for AP induction to study the contribution of the Na-Ca exchanger 1 (NCX1) ion channel in AP pathogenesis.