Open AccessActivation of the Nuclear Factor-kappa B Signaling Pathway Damages the Epithelial Barrier in the Human Pancreatic Ductal Adenocarcinoma Cell Line HPAF-II
Author(s) -
Shanshan Zhou,
Yahui Gong,
Huiying Yang,
Dehai Deng,
Zhihai Liang
Publication year - 2019
Publication title -
pancreas
Language(s) - English
Resource type - Journals
eISSN - 1536-4828
pISSN - 0885-3177
DOI - 10.1097/mpa.0000000000001441
Subject(s) - pyrrolidine dithiocarbamate , tight junction , adherens junction , myosin light chain kinase , nf κb , cancer research , nfkb1 , tumor necrosis factor alpha , pancreatic duct , signal transduction , chemistry , biology , microbiology and biotechnology , cadherin , pancreas , transcription factor , cell , endocrinology , phosphorylation , biochemistry , gene
Injury of the pancreatic duct epithelial barrier plays a critical role in the development of acute pancreatitis. The activity of the nuclear factor-kappa B (NF-κB) pathway is involved in the disruption of the pancreatic duct epithelial barrier. This study investigated how NF-κB impacts the dysfunction of the pancreatic duct epithelial barrier.