Open AccessRethinking the multiple roles of B cells in organ transplantation
Author(s) -
Verônica Coelho,
David Saitovitch,
Jorge Kalil,
Hernandez Moura Silva
Publication year - 2013
Publication title -
current opinion in organ transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.832
H-Index - 51
eISSN - 1531-7013
pISSN - 1087-2418
DOI - 10.1097/mot.0b013e32835c8043
Subject(s) - regulatory b cells , transplantation , organ transplantation , immunology , phenotype , medicine , b cell , biology , antibody , genetics , gene
To discuss the B-cell diverse functions in organ transplantation, highlighting the emerging debate on the role of regulatory B cells (Bregs). We underscore the need to re-examine and integrate data on B-cell functional activities, aiming to discriminate their regulatory (REG) and inflammatory (INFLAMMA) functions and to translate this knowledge for the development of novel immunomodulatory therapeutic strategies and to rethink the current ones.