Open AccessImpact of extracellular vesicles on innate immunity
Author(s) -
Zhizhao Chen,
Adriana T. Larregina,
Adrián E. Morelli
Publication year - 2019
Publication title -
current opinion in organ transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.832
H-Index - 51
eISSN - 1531-7013
pISSN - 1087-2418
DOI - 10.1097/mot.0000000000000701
Subject(s) - microvesicles , extracellular vesicle , microbiology and biotechnology , innate immune system , extracellular , biology , vesicle , microvesicle , immune system , immunology , biochemistry , microrna , membrane , gene
Extracellular vesicles released by prokaryote or eukaryote cells are emerging as mechanisms of cell-to-cell communication, by either physically interacting with the surface of target cells or transferring proteins/peptides, lipids, carbohydrates, and nuclei acids to acceptor cells. Accumulating evidence indicates that extracellular vesicles, among other functions, regulate innate and adaptive immune responses. We revisit here the effects that extracellular vesicles of various origins have on innate immunity.