Open AccessLung bioengineering: advances and challenges in lung decellularization and recellularization
Author(s) -
Juan J. Uriarte,
Franziska E. Uhl,
Sara Rolandsson Enes,
Robert A. Pouliot,
Daniel J. Weiss
Publication year - 2018
Publication title -
current opinion in organ transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.832
H-Index - 51
eISSN - 1531-7013
pISSN - 1087-2418
DOI - 10.1097/mot.0000000000000584
Subject(s) - decellularization , lung , tissue engineering , economic shortage , regeneration (biology) , medicine , artificial lung , extracellular matrix , repopulation , biomedical engineering , stem cell , biology , microbiology and biotechnology , linguistics , philosophy , anesthesia , government (linguistics) , haematopoiesis
Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced rapidly to combine scaffolds, cells, and biologically active molecules into functional tissues to restore or improve the lung's main function, gas exchange. This review will inspect the current progress in lung bioengineering using decellularized and recellularized lung scaffolds and highlight future challenges in the field.