Open AccessTargeting tumor microenvironment and metastasis in children with solid tumors
Author(s) -
Kristin M. Wessel,
Rosandra N. Kaplan
Publication year - 2021
Publication title -
current opinion in pediatrics, with evaluated medline/current opinion in pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 87
eISSN - 1080-8116
pISSN - 1040-8703
DOI - 10.1097/mop.0000000000001082
Subject(s) - medicine , tumor microenvironment , stromal cell , immunotherapy , solid tumor , metastasis , immune system , cancer research , immunology , cancer
The prognosis of pediatric patients with metastatic solid tumors remains poor, necessitating development of novel therapeutic strategies. The biology of the pediatric tumor microenvironment (TME) presents obstacles for the efficacy of current therapeutic approaches including immunotherapies. Targeting various aspects of the TME in pediatric patients with solid tumors represents a therapeutic opportunity that may improve outcomes. Here we will discuss recent advances in characterization of the TME, and clinical advances in targeting the immune, vascular, and stromal aspects of the TME.