Open AccessPharmacogenomics insights into precision pediatric oncology
Author(s) -
Kristie N. Ramos,
David Gregornik,
Kenneth S. Ramos
Publication year - 2021
Publication title -
current opinion in pediatrics, with evaluated medline/current opinion in pediatrics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 87
eISSN - 1080-8116
pISSN - 1040-8703
DOI - 10.1097/mop.0000000000001065
Subject(s) - medicine , pharmacogenomics , dosing , thiopurine methyltransferase , pharmacogenetics , oncology , cardiotoxicity , intensive care medicine , precision medicine , anthracycline , pharmacology , bioinformatics , cancer , toxicity , biochemistry , chemistry , disease , biology , breast cancer , genotype , inflammatory bowel disease , gene , pathology
Pharmacogenomic insights provide an opportunity to optimize medication dosing regimens and patient outcomes. However, the potential for interindividual genomic variability to guide medication dosing and toxicity monitoring is not yet standard of care. In this review, we present advances for the thiopurines, anthracyclines and vincristine and provide perspectives on the actionability of pharmacogenomic guidance in the future.