Open AccessGenetic susceptibility to fungal infection in children
Author(s) -
Sebastian Ochoa,
Gregory Constantine,
Michail S. Lionakis
Publication year - 2020
Publication title -
current opinion in pediatrics, with evaluated medline/current opinion in pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 87
eISSN - 1080-8116
pISSN - 1040-8703
DOI - 10.1097/mop.0000000000000948
Subject(s) - medicine , immunosuppression , immunology , immune system , disease , immunodeficiency , immunity , primary immunodeficiency , incidence (geometry) , population , aspergillosis , intensive care medicine , pathology , environmental health , physics , optics
Fungal infections have steadily increased in incidence, emerging as a significant cause of morbidity and mortality in patients with iatrogenic immunosuppression. Simultaneously, we have witnessed a growing population of newly described inherited immune disorders that have enhanced our understanding of the human immune response against fungi. In the present review, we provide an overview and diagnostic roadmap to inherited disorders which confer susceptibility to superficial and invasive fungal infections.