Open AccessUpdate on adrenarche
Author(s) -
Selma F. Witchel,
Bianca Carollyne Martins Pinto,
Anne Claire Burghard,
Sharon E. Oberfield
Publication year - 2020
Publication title -
current opinion in pediatrics, with evaluated medline/current opinion in pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 87
eISSN - 1080-8116
pISSN - 1040-8703
DOI - 10.1097/mop.0000000000000928
Subject(s) - adrenarche , zona reticularis , endocrinology , dehydroepiandrosterone sulfate , intracrine , medicine , adrenal cortex , dehydroepiandrosterone , pubic hair , adrenal gland , hormone , zona glomerulosa , androgen , receptor , paracrine signalling , angiotensin ii
Adrenarche is the pubertal maturation of the innermost zone of the adrenal cortex, the zona reticularis. The onset of adrenarche occurs between 6 and 8 years of age when dehydroepiandrosterone sulfate (DHEAS) concentrations increase. This review provides an update on adrenal steroidogenesis and the differential diagnosis of premature development of pubic hair.