Open AccessMetabolic regulation of macrophage proliferation and function in atherosclerosis
Author(s) -
Michael T. Patterson,
Jesse W. Williams
Publication year - 2021
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000778
Subject(s) - macrophage , lipid metabolism , function (biology) , biology , foam cell , cell growth , microbiology and biotechnology , inflammation , cytokine , cell , phenotype , immunology , biochemistry , in vitro , gene
Macrophage accumulation within atherosclerotic plaque is a primary driver of disease progression. However, recent advances in both phenotypic and functional heterogeneity of these cells have allowed for improved insight into potential regulation of macrophage function within lesions. In this review, we will discuss recent insights on macrophage heterogeneity, lipid processing, metabolism, and proliferation in atherosclerosis. Furthermore, we will identify outstanding questions in the field that are pertinent to future studies.