Open AccessExtracellular matrix: paving the way to the newest trends in atherosclerosis
Author(s) -
Chrysostomi Gialeli,
Annelie Shami,
Isabel Gonçalves
Publication year - 2021
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000775
Subject(s) - extracellular matrix , proinflammatory cytokine , elastin , glycosaminoglycan , microbiology and biotechnology , phenotype , medicine , fibrosis , disease , inflammation , pathology , chemistry , immunology , biology , biochemistry , anatomy , gene
The extracellular matrix (ECM) is critical for all aspects of vascular pathobiology. In vascular disease the balance of its structural components is shifted. In atherosclerotic plaques there is in fact a dynamic battle between stabilizing and proinflammatory responses. This review explores the most recent strides that have been made to detail the active role of the ECM - and its main binding partners - in driving atherosclerotic plaque development and destabilization.