Open AccessCompeting tissue-specific functions for the Tribbles-1 plasma lipid associated locus
Author(s) -
Krista Y. Hu,
Robert C. Bauer
Publication year - 2021
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000748
Subject(s) - regulator , phenotype , genome wide association study , biology , function (biology) , computational biology , genetic association , bioinformatics , microbiology and biotechnology , cancer research , genetics , gene , single nucleotide polymorphism , genotype
The pseudokinase Tribbles-1 (TRIB1) remains the focus of intense research since genome-wide association studies (GWAS) associated it with multiple cardiometabolic traits in humans, including plasma lipids and atherosclerosis. This review highlights recent advances in understanding the function of TRIB1 and what outstanding questions remain.