Open AccessMonocytes and macrophages in atherogenesis
Author(s) -
Jaume Amengual,
Tessa J. Barrett
Publication year - 2019
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000634
Subject(s) - myelopoiesis , macrophage , context (archaeology) , immunology , phenotype , monocyte , biology , microbiology and biotechnology , haematopoiesis , medicine , stem cell , gene , genetics , in vitro , paleontology
Monocytes and macrophages are key players in the pathogenesis of atherosclerosis and dictate atherogenesis growth and stability. The heterogeneous nature of myeloid cells concerning their metabolic and phenotypic function is increasingly appreciated. This review summarizes the recent monocyte and macrophage literature and highlights how differing subsets contribute to atherogenesis.