Open AccessLeveraging information from genetic risk scores of coronary atherosclerosis
Author(s) -
Themistocles L. Assimes,
Elias Salfati,
Liana C. Del Gobbo
Publication year - 2017
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000400
Subject(s) - genome wide association study , coronary artery disease , medicine , genetic association , single nucleotide polymorphism , coronary atherosclerosis , cohort , bioinformatics , cardiology , genetics , gene , biology , genotype
Genome-wide association studies (GWAS) have identified ∼60 loci for coronary artery disease (CAD). Through genetic risk scores (GRSs), investigators are leveraging this genomic information to gain insights on both the fundamental mechanisms driving these associations as well as their utility in improving risk prediction.