Open AccessProthrombotic state associated with preeclampsia
Author(s) -
ChoongHee Han,
Yuanyuan Chen,
Jing–fei Dong
Publication year - 2021
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000678
Subject(s) - preeclampsia , medicine , pregnancy , thrombophilia , thrombosis , placenta , obstetrics , fetus , biology , genetics
Preeclampsia is a common complication of pregnancy and contributes significantly to maternal and fetal morbidity and mortality. A protective hypercoagulable state is often developed during late pregnancy and can evolve into a prothrombotic state in patients with preeclampsia. The underlying mechanism of this prothrombotic transition remains poorly understood. We discuss recent progress in understanding the pathophysiology of preeclampsia and associated prothrombotic state.