Open AccessThe Nlrp3 inflammasome – the evolving story of its positive and negative effects on hematopoiesis
Author(s) -
Mariusz Z. Ratajczak,
Magdalena Kucia
Publication year - 2021
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000658
Subject(s) - inflammasome , innate immune system , haematopoiesis , pyroptosis , biology , microbiology and biotechnology , homing (biology) , progenitor cell , bone marrow , immunology , stem cell , immune system , inflammation , ecology
Hematopoiesis is co-regulated by innate immunity, which is an ancient evolutionary defense mechanism also involved in the development and regeneration of damaged tissues. This review seeks to shed more light on the workings of the Nlrp3 inflammasome, which is an intracellular innate immunity pattern recognition receptor and sensor of changes in the hematopoietic microenvironment, and focus on its role in hematopoieisis.