Open AccessCellular components of the hematopoietic niche and their regulation of hematopoietic stem cell function
Author(s) -
Joydeep Ghosh,
Roy El Koussa,
Safa Mohamad,
Jianyun Liu,
Melissa A. Kacena,
Edward F. Srour
Publication year - 2021
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000656
Subject(s) - haematopoiesis , niche , stem cell , microbiology and biotechnology , biology , hematopoietic stem cell , progenitor cell , transcriptome , function (biology) , genetics , gene , gene expression , biochemistry
Development and functions of hematopoietic stem cells (HSC) are regulated by multiple cellular components of the hematopoietic niche. Here we review the recent advances in studying the role of three such components -- osteoblasts, osteomacs, and megakaryocytes and how they interact with each other in the hematopoietic niche to regulate HSC.