Open Access‘Enhancing’ red cell fate through epigenetic mechanisms
Author(s) -
Marlies P. Rossmann,
Leonard I. Zon
Publication year - 2021
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000654
Subject(s) - chromatin , epigenetics , bivalent chromatin , biology , histone modifying enzymes , enhancer , chia pet , histone , epigenomics , chromatin remodeling , transcription factor , chromosome conformation capture , computational biology , pioneer factor , dna methylation , microbiology and biotechnology , genetics , regulation of gene expression , transcription coregulator , gene , gene expression
Transcription of erythroid-specific genes is regulated by the three-dimensional (3D) structure and composition of chromatin, which dynamically changes during erythroid differentiation. Chromatin organization and dynamics are regulated by several epigenetic mechanisms involving DNA (de-)methylation, posttranslational modifications (PTMs) of histones, chromatin-associated structural proteins, and higher-order structural changes and interactions. This review addresses examples of recent developments in several areas delineating the interface of chromatin regulation and erythroid-specific lineage transcription.