Open AccessProteomic/transcriptomic analysis of erythropoiesis
Author(s) -
Marjorie Brand,
Jeffrey A. Ranish
Publication year - 2021
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000647
Subject(s) - erythropoiesis , proteomics , biology , transcriptome , computational biology , haematopoiesis , quantitative proteomics , stem cell , bioinformatics , microbiology and biotechnology , gene expression , gene , genetics , medicine , anemia
Erythropoiesis is a hierarchical process by which hematopoietic stem cells give rise to red blood cells through gradual cell fate restriction and maturation. Deciphering this process requires the establishment of dynamic gene regulatory networks (GRNs) that predict the response of hematopoietic cells to signals from the environment. Although GRNs have historically been derived from transcriptomic data, recent proteomic studies have revealed a major role for posttranscriptional mechanisms in regulating gene expression during erythropoiesis. These new findings highlight the need to integrate proteomic data into GRNs for a refined understanding of erythropoiesis.