Open AccessThe N6-methyladenosine RNA modification in acute myeloid leukemia
Author(s) -
Eliza Yankova,
Demetrios Aspris,
Konstantinos Tzelepis
Publication year - 2020
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000636
Subject(s) - demethylase , myeloid leukemia , rna , n6 methyladenosine , methyltransferase , biology , leukemia , haematopoiesis , rna methylation , cancer research , gene , stem cell , computational biology , bioinformatics , microbiology and biotechnology , genetics , epigenetics , methylation
In recent years, the N6-methyladenosine (m6A) modification of RNA has been shown to play an important role in the development of acute myeloid leukemia (AML) and the maintenance of leukemic stem cells (LSCs). In this review we summarise the recent findings in the field of epitranscriptomics related to m6A and its relevance in AML.