Open AccessGenetic heterogeneity and clonal evolution in acute myeloid leukemia
Author(s) -
Jennifer S. Romer-Seibert,
Sara E. Meyer
Publication year - 2020
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000626
Subject(s) - somatic evolution in cancer , myeloid leukemia , genetic heterogeneity , biology , clonal selection , computational biology , dna sequencing , genomics , leukemia , myeloid , genetics , genome , immunology , cancer , dna , gene , phenotype
Clonal heterogeneity is a significant obstacle to successful treatment of patients with acute myeloid leukemia (AML). Here, we review new advances in the understanding of genetic heterogeneity in AML using single-cell DNA-sequencing technology.