Open AccessStudying clonal evolution of myeloid malignancies using induced pluripotent stem cells
Author(s) -
Sergei Doulatov,
Eirini P. Papapetrou
Publication year - 2021
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000620
Subject(s) - reprogramming , somatic evolution in cancer , biology , induced pluripotent stem cell , somatic cell , myeloid leukemia , myeloid , haematopoiesis , stem cell , cancer research , computational biology , genetics , cell , cancer , gene , embryonic stem cell
Myeloid malignancies comprise a spectrum of genetically heterogeneous disorders marked by the stepwise acquisition of somatic mutations and clonal evolution. The blood and bone marrow of patients typically consists of a mix of different clones and subclones along the path of clonal evolution that cannot be deconvoluted with most current approaches. Here, we review the application of induced pluripotent stem cell (iPSC) technology to the study of the clonal architecture and clonal evolution of these diseases, focusing on myelodysplastic syndromes and acute myeloid leukemia.