Open AccessGermline mutations: many roles in leukemogenesis
Author(s) -
Kevin Z Chen,
Rafi Kazi,
Christopher C. Porter,
ChengKui Qu
Publication year - 2020
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000596
Subject(s) - germline , somatic cell , germline mutation , biology , leukemia , mutation , cancer research , bone marrow , haematopoiesis , somatic evolution in cancer , stem cell , genetics , cancer , immunology , gene
The purpose of this review is to summarize the current understanding of germline mutations as they contribute to leukemia development and progression. We also discuss how these new insights may help improve clinical management of germline mutations associated with leukemia.