Open AccessIn vivo and ex vivo haematopoietic stem cell expansion
Author(s) -
Ryō Yamamoto,
Adam C. Wilkinson,
Hiromitsu Nakauchi
Publication year - 2020
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000593
Subject(s) - haematopoiesis , ex vivo , stem cell , hematology , transplantation , biology , bone marrow , in vivo , immunology , cancer research , medicine , microbiology and biotechnology
Haematopoietic stem cells (HSCs) are characterized by two key features: self-renewal ability and multilineage differentiation potential. Through these cellular activities, HSCs sustain blood and immune system homeostasis throughout life and can also reconstitute the entire haematopoietic system within a bone marrow ablated recipient. This approach of HSC transplantation is used clinically as a curative treatment option for numerous haematological diseases, both malignant and nonmalignant.