Open AccessSingle-cell fate decisions of bipotential hematopoietic progenitors
Author(s) -
Marjorie Brand,
Edward Morrissey
Publication year - 2020
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000592
Subject(s) - haematopoiesis , cell fate determination , progenitor cell , biology , microbiology and biotechnology , stem cell , cell , hematopoietic cell , hematopoietic stem cell , fate mapping , niche , transcription factor , immunology , genetics , biochemistry , gene
In hematopoiesis, rapid cell fate decisions are necessary for timely responses to environmental stimuli resulting in the production of diverse types of blood cells. Early studies have led to a hierarchical, tree-like view of hematopoiesis with hematopoietic stem cells residing at the apex and serially branching out to give rise to bipotential progenitors with increasingly restricted lineage potential. Recent single-cell studies have challenged some aspects of the classical model of hematopoiesis. Here, we review the latest articles on cell fate decision in hematopoietic progenitors, highlighting single-cell studies that have questioned previously established concepts and those that have reaffirmed them.