Open AccessANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis
Author(s) -
Carlos FernándezHernando,
Yajaira Suárez
Publication year - 2020
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000580
Subject(s) - angptl4 , lipid metabolism , lipoprotein lipase , biology , angiopoietin , bioinformatics , medicine , adipose tissue , microbiology and biotechnology , cancer research , endocrinology , biochemistry , vascular endothelial growth factor , gene , vegf receptors
Since the first discovery of Angiopoetin-like 4 (ANGPTL4) in 2000, the involvement of ANGPTL4 in different aspects of lipid metabolism and vascular biology has emerged as an important research field. In this review, we summarize the fundamental roles of ANGPTL4 in regulating metabolic and nonmetabolic functions and their implication in lipid metabolism and with several aspects of vascular function and dysfunction.