Open AccessActivated protein C in neuroprotection and malaria
Author(s) -
Laurent O. Mosnier
Publication year - 2019
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000528
Subject(s) - neuroprotection , protein c , medicine , endothelial protein c receptor , stroke (engine) , immunology , coagulation , pathophysiology , neuroscience , pharmacology , bioinformatics , biology , thrombin , platelet , mechanical engineering , engineering
Activated protein C (APC) is a homeostatic coagulation protease with anticoagulant and cytoprotective activities. Focusing on APC's effects in the brain, this review discusses three different scenarios that illustrate how APC functions are intimately affecting the physiology and pathophysiology of the brain.