Open AccessThe role of mucosal immunity and host genetics in defining intestinal commensal bacteria
Author(s) -
Jonathan J. Hansen,
Ajay Gulati,
R. Balfour Sartor
Publication year - 2010
Publication title -
current opinion in gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.165
H-Index - 83
eISSN - 1531-7056
pISSN - 0267-1379
DOI - 10.1097/mog.0b013e32833f1195
Subject(s) - biology , dysbiosis , faecalibacterium prausnitzii , innate immune system , commensalism , nod2 , immune system , microbiology and biotechnology , microbiome , immunity , gut flora , immunology , pattern recognition receptor , antimicrobial peptides , bacteria , genetics , antimicrobial
Dramatic advances in molecular characterization of the largely noncultivable enteric microbiota have facilitated better understanding of the composition of this complex ecosystem at broad phylogenetic levels. This review outlines current understanding of mechanisms by which commensal bacteria are controlled and shaped into functional communities by innate and adaptive immune responses, antimicrobial peptides produced by epithelial cells and host genetic factors.