Paneth cells and innate mucosal immunity | Zendy

André J. Ouellette | Zendy

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Paneth cells and innate mucosal immunity

Author(s) -

André J. Ouellette

Publication year - 2010

Publication title -

current opinion in gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.165

H-Index - 83

eISSN - 1531-7056

pISSN - 0267-1379

DOI - 10.1097/mog.0b013e32833dccde

Subject(s) - paneth cell , endoplasmic reticulum , biology , microbiology and biotechnology , crypt , proinflammatory cytokine , autophagy , immunology , xbp1 , unfolded protein response , inflammatory bowel disease , inflammation , homeostasis , innate immune system , pathogenesis , immune system , apoptosis , disease , pathology , small intestine , medicine , genetics , gene , biochemistry , endocrinology , rna , rna splicing

Recent evidence shows that disruption of Paneth cell homeostasis by induction of endoplasmic reticulum stress or autophagy, with consequent apoptosis, contributes to inflammation and morbidity in a variety of experimental mouse models.

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