Open AccessPaneth cells and innate mucosal immunity
Author(s) -
André J. Ouellette
Publication year - 2010
Publication title -
current opinion in gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.165
H-Index - 83
eISSN - 1531-7056
pISSN - 0267-1379
DOI - 10.1097/mog.0b013e32833dccde
Subject(s) - paneth cell , endoplasmic reticulum , biology , microbiology and biotechnology , crypt , proinflammatory cytokine , autophagy , immunology , xbp1 , unfolded protein response , inflammatory bowel disease , inflammation , homeostasis , innate immune system , pathogenesis , immune system , apoptosis , disease , pathology , small intestine , medicine , genetics , gene , biochemistry , endocrinology , rna , rna splicing
Recent evidence shows that disruption of Paneth cell homeostasis by induction of endoplasmic reticulum stress or autophagy, with consequent apoptosis, contributes to inflammation and morbidity in a variety of experimental mouse models.