Open AccessMicrobial influences on the small intestinal response to radiation injury
Author(s) -
Christopher D. Packey,
Matthew A. Ciorba
Publication year - 2010
Publication title -
current opinion in gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.165
H-Index - 83
eISSN - 1531-7056
pISSN - 0267-1379
DOI - 10.1097/mog.0b013e3283361927
Subject(s) - immune system , microbiome , innate immune system , enteropathy , biology , immunology , disease , medicine , cancer research , bioinformatics , pathology
Injury to the small bowel from ionizing radiation occurs commonly in patients undergoing cancer therapy and less commonly in instances of accidental radiation overexposure. Several lines of evidence now suggest that dynamic interactions between the host's enteric microbiota and innate immune system are important in modulating the intestinal response to radiation. Here, we will review recent developments in the area of acute radiation enteropathy and examine the current state of knowledge regarding the impact of host-microbial interactions in the process.