Open AccessSynthetic human livers for modeling metabolic diseases
Author(s) -
Edgar N. Tafaleng,
Michelle R Malizio,
Ira J. Fox,
Alejandro Soto-Gutiérrez
Publication year - 2021
Publication title -
current opinion in gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.165
H-Index - 83
eISSN - 1531-7056
pISSN - 0267-1379
DOI - 10.1097/mog.0000000000000726
Subject(s) - induced pluripotent stem cell , biofabrication , computational biology , biology , liver disease , human liver , personalized medicine , bioinformatics , regenerative medicine , stem cell , neuroscience , gene , tissue engineering , microbiology and biotechnology , embryonic stem cell , genetics , biochemistry , in vitro
In this review, we will explore recent advances in human induced pluripotent stem cell (iPSC)-based modeling of metabolic liver disease and biofabrication of synthetic human liver tissue while also discussing the emerging concept of synthetic biology to generate more physiologically relevant liver disease models.