Open AccessProduction of copper-64 using a hospital cyclotron: targetry, purification and quality analysis
Author(s) -
Maite Jauregui-Osoro,
Simona De Robertis,
P. Halsted,
Sarah-May Gould,
Zilin Yu,
Rowena L. Paul,
Paul Marsden,
Antony D. Gee,
Andrew Fenwick,
Philip J. Blower
Publication year - 2021
Publication title -
nuclear medicine communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.489
H-Index - 73
eISSN - 1473-5628
pISSN - 0143-3636
DOI - 10.1097/mnm.0000000000001422
Subject(s) - radiochemistry , elution , hydrochloric acid , chemistry , trace metal , copper , nuclear chemistry , contamination , ion exchange , dissolution , nickel , metal , chromatography , ion , inorganic chemistry , organic chemistry , ecology , biology
To construct and evaluate a 64Cu production system that minimises the amount of costly 64Ni, radionuclidic impurities and nonradioactive metal contamination and maximises radiochemical and radionuclidic purity and molar activity; and to report analytical and quality control methods that can be used within typical PET radiochemistry production facilities to measure metal ion concentrations and radiometal molar activities.