Open AccessContribution of Th17 cells to tissue injury in hypertension
Author(s) -
David P. Basile,
Justine M. AbaisBattad,
David L. Mattson
Publication year - 2020
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000680
Subject(s) - immune system , inflammation , medicine , fibrosis , disease , immunology , kidney disease , kidney , exacerbation , renal sodium reabsorption , reabsorption , bioinformatics , biology
Hypertension has been demonstrated to be a chief contributor to morbidity and mortality throughout the world. Although the cause of hypertension is multifactorial, emerging evidence, obtained in experimental studies, as well as observational studies in humans, points to the role of inflammation and immunity. Many aspects of immune function have now been implicated in hypertension and end-organ injury; this review will focus upon the recently-described role of Th17 cells in this pathophysiological response.