Open AccessMolecular regulation and function of FoxO3 in chronic kidney disease
Author(s) -
Fangming Lin
Publication year - 2020
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000616
Subject(s) - foxo3 , transcription factor , autophagy , sod2 , microbiology and biotechnology , proteostasis , biology , oxidative stress , hypoxia (environmental) , hypoxia inducible factors , cell fate determination , cancer research , chemistry , superoxide dismutase , apoptosis , gene , biochemistry , oxygen , organic chemistry
FOXOs are transcription factors that regulate downstream target genes to counteract to cell stress. Here we review the function and regulation of FOXO transcription factors, the mechanism of FOXO3 activation in the kidney, and the role of FOXO3 in delaying the development of chronic kidney disease (CKD).