Open AccessPPARγ and RhoBTB1 in hypertension
Author(s) -
Shi Fang,
Curt D. Sigmund
Publication year - 2020
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000579
Subject(s) - vascular smooth muscle , peroxisome proliferator activated receptor , microbiology and biotechnology , cullin , ubiquitin ligase , vasodilation , nitric oxide , receptor , ubiquitin , chemistry , pharmacology , medicine , biology , endocrinology , biochemistry , gene , smooth muscle
This review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle.