Open AccessIn-vivo techniques for determining nephron number
Author(s) -
Aleksandar Denic,
Hisham E. Elsherbiny,
Andrew D. Rule
Publication year - 2019
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000540
Subject(s) - nephron , kidney disease , renal function , medicine , urology , kidney , glomerular hyperfiltration , albuminuria , pathology , endocrinology , diabetic nephropathy
Many studies have suggested low nephron endowment at birth contributes to the risk of developing hypertension and chronic kidney disease (CKD) later in life. Loss of nephrons with age and disease is largely a subclinical process. New technologies are needed to count nephrons as glomerular filtration rate (GFR) is a poor surrogate for nephron number.