Open AccessCullin-Ring ubiquitin ligases in kidney health and disease
Author(s) -
Ryan J. Cornelius,
Mohammed Z. Ferdaus,
Jonathan W. Nelson,
James A. McCormick
Publication year - 2019
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000527
Subject(s) - cullin , ubiquitin ligase , ubiquitin , microbiology and biotechnology , biology , kidney , kidney disease , bioinformatics , cancer research , medicine , endocrinology , biochemistry , gene
Members of the Cullin family act as scaffolds in E3 ubiquitin ligases and play a central role in mediating protein degradation. Interactions with many different substrate-binding adaptors permit Cullin-containing E3 ligases to participate in diverse cellular functions. In the kidney, one well established target of Cullin-mediated degradation is the transcription factor Nrf2, a key player in responses to oxidative stress. The goal of this review is to discuss more recent findings revealing broader roles for Cullins in the kidney.