Open AccessThe Drosophila Malpighian tubule as a model for mammalian tubule function
Author(s) -
Aylin R. Rodan
Publication year - 2019
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000521
Subject(s) - malpighian tubule system , drosophila melanogaster , microbiology and biotechnology , biology , tubule , biochemistry , gene , genetics , kidney , botany , larva , midgut
Studies of the genetic model organism, Drosophila melanogaster, have unraveled molecular pathways relevant to human physiology and disease. The Malpighian tubule, the Drosophila renal epithelium, is described here, including tools available to study transport; conserved transporters, channels, and the signaling pathways regulating them; and fly models of kidney stone disease.