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Paradigms and Progress in Vocal Fold Restoration
Author(s) -
Ford Charles N.,
Baker Daniel C.
Publication year - 2008
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/mlg.0b013e31817c03c3
Subject(s) - leaps , criticism , regeneration (biology) , paradigm shift , biology , engineering ethics , cognitive science , psychology , epistemology , political science , engineering , philosophy , genetics , financial economics , law , economics
Science advances occur through orderly steps, puzzle‐solving leaps, or divergences from the accepted disciplinary matrix that occasionally result in a revolutionary paradigm shift. Key advances must overcome bias, criticism, and rejection. Examples in biological science include use of embryonic stem cells, recognition of Helicobacter pylori in the etiology of ulcer disease, and the evolution of species. Our work in vocal fold restoration reflects these patterns. We progressed through phases of tissue replacement with fillers and biological implants, to current efforts at vocal fold regeneration through tissue engineering, and face challenges of a new “systems biology” paradigm embracing genomics and proteomics.