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Optical Coherence Tomography of the Cochlea in the Porcine Model
Author(s) -
Sepehr Ali,
Djalilian Hamid R.,
Chang Janice E.,
Chen Zhongping,
Wong Brian J. F.
Publication year - 2008
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/mlg.0b013e318173dd6c
Subject(s) - cochlea , optical coherence tomography , tectorial membrane , basilar membrane , cochlear duct , temporal bone , anatomy , inner ear , x ray microtomography , tomography , medicine , radiology
Objectives/Hypothesis: To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea. Study Design: Ex vivo, porcine model. Methods: Optical coherence tomographic images of the porcine cochlea were obtained by thinning the bone from the basal turn of the cochlea leaving the endosteum intact. The images were compared with the corresponding histological sections. Results: In the areas of thinned bone, images were obtained of the stria vascularis, Reissner's membrane, basilar membrane, tectorial membrane, scala media, scala tympani, and scala vestibuli. The bone was too thick for adequate light penetration in the areas where it was not thinned. Good histological correlation was obtained. Conclusions: Cochlear and vestibular microanatomic structures of the pig cochlea were clearly identified with histological confirmation, suggesting the potential application of this noninvasive imaging modality for in vivo imaging of the human cochlea.