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Collagen Fiber and Versican Distribution Within the Lamina Propria of Fetal Vocal Folds
Author(s) -
Buhler Rogerio Borghi,
Sennes Luiz U.,
Mauad Thais,
Melo Erich Christiano M.,
Silva Luiz Fernando F.,
Saldiva Paulo Hilário N.
Publication year - 2008
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/mlg.0b013e318159aa0d
Subject(s) - versican , lamina propria , vocal folds , anatomy , biology , larynx , proteoglycan , epithelium , cartilage , genetics
Objectives: To analyze the presence and distribution of collagen fibers and versican in human vocal fold lamina propria of fetal larynges. Study Design: Cross sectional analysis of cadaveric vocal folds of human fetuses. Methods: Seven fetal larynges obtained from 28‐ to 36‐week‐old fetuses were analyzed with the Picrosirius‐polarization method, immunohistochemistry, and image analysis. Results: Collagen fibers within the lamina propria exhibited a monolaminar distribution pattern and spatial arrangement in “wicker basket.” Versican distribution was larger in the superficial and intermediate layers when compared to the deep layer. Conclusion: Our findings suggest that collagen and versican distribution and arrangement within the lamina propria in the developing fetus are important for vocalization at birth.