Open AccessLeucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial
Author(s) -
Candida J. Rebello,
Michael B. Zemel,
Orville G. Kolterman,
Gilbert Alexander Fleming,
Frank L. Greenway
Publication year - 2021
Publication title -
american journal of therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 62
eISSN - 1536-3686
pISSN - 1075-2765
DOI - 10.1097/mjt.0000000000001303
Subject(s) - medicine , metformin , weight loss , placebo , adverse effect , randomized controlled trial , clinical endpoint , body mass index , population , leucine , endocrinology , sildenafil , post hoc analysis , combination therapy , pharmacology , obesity , diabetes mellitus , amino acid , biochemistry , chemistry , alternative medicine , environmental health , pathology
This study evaluated the potential of activating the fuel-sensing enzymes Adenine monophosphate (AMP)-activated protein kinase and the deacetylase sirtuin1, to promote weight loss. We tested the efficacy of a fixed dose combination of the amino acid leucine and 2 well-characterized agents with established safety profiles to modulate energy metabolism and facilitate weight loss.