Open AccessVitamin D Supplementation in COVID-19 Patients: A Clinical Case Series
Author(s) -
Kim C. Ohaegbulam,
Mohamed Swalih,
Pranavkumar Patel,
Miriam A. Smith,
Richard G. Perrin
Publication year - 2020
Publication title -
american journal of therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 62
eISSN - 1536-3686
pISSN - 1075-2765
DOI - 10.1097/mjt.0000000000001222
Subject(s) - medicine , vitamin d and neurology , proinflammatory cytokine , vitamin , cholecalciferol , calcitriol receptor , regimen , clinical trial , gastroenterology , inflammation
Coronavirus disease 2019 (COVID-19) has infected more than 4.4 million people and caused more than 300,000 deaths partly through acute respiratory distress syndrome with propensity to affect African American and Hispanic communities disproportionately. Patients with worse outcomes have exhibited higher blood plasma levels of proinflammatory cytokines. Activation of the vitamin D receptor expressed on immune cells has been shown to directly reduce the secretion of inflammatory cytokines, such as interleukin-6, and indirectly affect C-reactive protein.