Antioxidant Properties of Mesalamine in Colitis Inhibit Phosphoinositide 3-Kinase Signaling in Progenitor Cells | Zendy

Elizabeth Managlia | Zendy; Rebecca B. Katzman | Zendy; Jeffrey B. Brown | Zendy; Terrence A. Barrett | Zendy

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Antioxidant Properties of Mesalamine in Colitis Inhibit Phosphoinositide 3-Kinase Signaling in Progenitor Cells

Author(s) -

Elizabeth Managlia,

Rebecca B. Katzman,

Jeffrey B. Brown,

Terrence A. Barrett

Publication year - 2013

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1097/mib.0b013e318297d741

Subject(s) - pten , tensin , pi3k/akt/mtor pathway , cancer research , reactive oxygen species , protein kinase b , signal transduction , phosphoinositide 3 kinase , colitis , chemistry , biology , microbiology and biotechnology , immunology

Mesalamine, 5-aminosalicylic acid (5-ASA), is a potent antioxidant and is known to enhance peroxisome proliferator-activated receptor γ activity in the intestine. Our previous studies suggested reduced Phosphoinositide 3-Kinase (PI3K)/β-catenin signaling as a mechanism for 5-ASA chemoprevention in chronic ulcerative colitis (CUC). We now hypothesize that 5-ASA mediates changes in intestinal epithelial cell (IEC) reactive oxygen species during colitis to affect phosphatase and tensin homolog (PTEN), PI3K, and β-catenin signaling.

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