Subclinical Inflammation with Increased Neutrophil Activity in Healthy Twin Siblings Reflect Environmental Influence in the Pathogenesis of Inflammatory Bowel Disease | Zendy

Yaroslava Zhulina | Zendy; Victoria HahnStrömberg | Zendy; Alia Shamikh | Zendy; Christer Peterson | Zendy; Anders Gustavsson | Zendy; Nils Nyhlin | Zendy; Anna Wickbom | Zendy; Johan Bohr | Zendy; Lennart Bodin | Zendy; Curt Tysk | Zendy; Marie Carlson | Zendy; Jonas Halfvarson | Zendy

Open Access

Subclinical Inflammation with Increased Neutrophil Activity in Healthy Twin Siblings Reflect Environmental Influence in the Pathogenesis of Inflammatory Bowel Disease

Author(s) -

Yaroslava Zhulina,

Victoria HahnStrömberg,

Alia Shamikh,

Christer Peterson,

Anders Gustavsson,

Nils Nyhlin,

Anna Wickbom,

Johan Bohr,

Lennart Bodin,

Curt Tysk,

Marie Carlson,

Jonas Halfvarson

Publication year - 2013

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1097/mib.0b013e318281f2d3

Subject(s) - calprotectin , ulcerative colitis , medicine , subclinical infection , inflammatory bowel disease , immunology , monozygotic twin , myeloperoxidase , pathogenesis , twin study , disease , dizygotic twin , inflammation , crohn's disease , gastroenterology , biology , heritability , genetics

The mechanisms behind increased fecal calprotectin (FC) in healthy relatives of patients with inflammatory bowel disease (IBD) are unknown. Our aims were to explore if there is a subclinical inflammation with increased neutrophil activity in healthy twin siblings in discordant twin pairs with IBD and to assess the influence of genetics in this context.

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