Relatively high risk for hepatocellular carcinoma in patients with primary biliary cirrhosis not responding to ursodeoxycholic acid | Zendy

Edith M.M. Kuiper | Zendy; Bettina E. Hansen | Zendy; Rob P. Adang | Zendy; Carin M.J. van Nieuwkerk | Zendy; Robin Timmer | Zendy; Joost P.H. Drenth | Zendy; Piet Spoelstra | Zendy; Hans T. Brouwer | Zendy; Johan P. Kuyvenhoven | Zendy; Henk R. van Buuren | Zendy

Open Access

Relatively high risk for hepatocellular carcinoma in patients with primary biliary cirrhosis not responding to ursodeoxycholic acid

Author(s) -

Edith M.M. Kuiper,

Bettina E. Hansen,

Rob P. Adang,

Carin M.J. van Nieuwkerk,

Robin Timmer,

Joost P.H. Drenth,

Piet Spoelstra,

Hans T. Brouwer,

Johan P. Kuyvenhoven,

Henk R. van Buuren

Publication year - 2010

Publication title -

european journal of gastroenterology and hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.881

H-Index - 102

eISSN - 1473-5687

pISSN - 0954-691X

DOI - 10.1097/meg.0b013e32834059e7

Subject(s) - medicine , gastroenterology , hepatocellular carcinoma , ursodeoxycholic acid , cirrhosis , primary biliary cirrhosis , bilirubin , risk factor , incidence (geometry) , optics , physics

The reported incidence of hepatocellular carcinoma (HCC) among patients with primary biliary cirrhosis (PBC) varies from 0.7-3.8%, whereas in cirrhotic patients the risk is considerably higher. Age, male sex, cirrhosis, and portal hypertension are reported risk factors. It has been suggested that ursodeoxycholic acid (UDCA) may protect against HCC. We aimed to define risk factors for the development of HCC at the time of PBC diagnosis and to identify, among patients treated with UDCA for a long term, a subgroup that could benefit from screening.

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