Open AccessDecreased number of colonic tuft cells in quiescent ulcerative colitis patients
Author(s) -
Sebastian Kjærgaard,
T. S. Jensen,
Ulrike Ries Feddersen,
Niels Bindslev,
Kaare V. Grunddal,
Steen Seier Poulsen,
Hanne B. Rasmussen,
Esben BudtzJørgensen,
Mark Berner-Hansen
Publication year - 2020
Publication title -
european journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.881
H-Index - 102
eISSN - 1473-5687
pISSN - 0954-691X
DOI - 10.1097/meg.0000000000001959
Subject(s) - ulcerative colitis , medicine , tuft , gastroenterology , colitis , pathogenesis , inflammatory bowel disease , pathology , disease , materials science , composite material
Colonic tuft cells are epithelial chemosensory cells involved in barrier integrity, modulation of inflammatory responses and gut homeostasis. Recent evidence indicates an involvement of tuft cells in ulcerative colitis pathogenesis, though mechanisms remain largely unknown.Here, we quantified the colonic tuft cell population in patients with quiescent ulcerative colitis as compared to patients without identified colonic disease (controls).