Open AccessCombination therapy of obeticholic acid and ursodeoxycholic acid in patients with primary biliary cholangitis who respond incompletely to ursodeoxycholic acid: a systematic review
Author(s) -
Xuan Li,
Min Liao,
Qiong Pan,
Xiaoxun Zhang,
Hong Yang,
Ying Peng,
Li Qiao,
Jiaquan Qu,
Jin Chai
Publication year - 2020
Publication title -
european journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.881
H-Index - 102
eISSN - 1473-5687
pISSN - 0954-691X
DOI - 10.1097/meg.0000000000001785
Subject(s) - medicine , ursodeoxycholic acid , obeticholic acid , gastroenterology , meta analysis , cochrane library , confidence interval , transaminase , aspartate transaminase , clinical endpoint , randomized controlled trial , combination therapy , alanine transaminase , alkaline phosphatase , biochemistry , chemistry , receptor , enzyme , agonist
Although the efficacy of ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) for primary biliary cholangitis (PBC) has been suggested by small trials, a meta-analysis to summarize the evidence has not yet been carried out. The aim of this study was to evaluate the clinical outcomes of the combination therapy of UDCA and OCA compared with UDCA monotherapy in patients with PBC.